The Next Generation of Clinical Decision Making Tools: Development of a Real-Time Prediction Tool for Outcome of Prostate Biopsy in Response to a Continuously Evolving Prostate Cancer Landscape.

ABSTRACT:

Purpose

We evaluate whether annual updating of the PCPT Risk Calculator would improve institutional validation compared to static use of the PCPT Risk Calculator alone.

Materials and methods

Data from 5 international cohorts including SABOR, Cleveland Clinic, ProtecT, Tyrol and Durham VA, comprising 18,400 biopsies, were used to evaluate an institution specific annual recalibration of the PCPT Risk Calculator. Using all prior years as a training set and the current year as the test set, annual recalibrations of the PCPT Risk Calculator were compared to static use of the PCPT Risk Calculator in terms of AUC and the Hosmer-Lemeshow goodness of fit statistic.

Results

For predicting high grade disease the median AUC (higher is better) of the recalibrated PCPT Risk Calcula

SUBMITTER: Strobl AN 

PROVIDER: S-EPMC4475467 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature