Ontology highlight
ABSTRACT:
SUBMITTER: Roe JS
PROVIDER: S-EPMC4475489 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Molecular cell 20150514 6
The bromodomain and extraterminal (BET) protein BRD4 is a validated drug target in leukemia, yet its regulatory function in this disease is not well understood. Here, we show that BRD4 chromatin occupancy in acute myeloid leukemia closely correlates with the hematopoietic transcription factors (TFs) PU.1, FLI1, ERG, C/EBPα, C/EBPβ, and MYB at nucleosome-depleted enhancer and promoter regions. We provide evidence that these TFs, in conjunction with the lysine acetyltransferase activity of p300/CB ...[more]