A hypothetical astrocyte-microglia lactate shuttle derived from a ¹H NMR metabolomics analysis of cerebrospinal fluid from a cohort of South African children with tuberculous meningitis.

ABSTRACT: Tuberculosis meningitis (TBM) is the most severe form of extra-pulmonary tuberculosis and is particularly intense in small children; there is no universally accepted algorithm for the diagnosis and substantiation of TB infection, which can lead to delayed intervention, a high risk factor for morbidity and mortality. In this study a proton magnetic resonance (¹H NMR)-based metabolomics analysis and several chemometric methods were applied to data generated from lumber cerebrospinal fluid (CSF) samples from three experimental groups: (1) South African infants and children with confirmed TBM, (2) non-meningitis South African infants and children as controls, and (3) neurological controls from the Netherlands. A total of 16 NMR-derived CSF metabolites were identified, which clearly

SUBMITTER: Mason S 

PROVIDER: S-EPMC4475545 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature