Ontology highlight
ABSTRACT:
SUBMITTER: Sekhar A
PROVIDER: S-EPMC4475725 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Sekhar Ashok A Rumfeldt Jessica A O JA Broom Helen R HR Doyle Colleen M CM Bouvignies Guillaume G Meiering Elizabeth M EM Kay Lewis E LE
eLife 20150623
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease involving cytotoxic conformations of Cu, Zn superoxide dismutase (SOD1). A major challenge in understanding ALS disease pathology has been the identification and atomic-level characterization of these conformers. Here, we use a combination of NMR methods to detect four distinct sparsely populated and transiently formed thermally accessible conformers in equilibrium with the native state of immature SOD1 (apoSOD1(2SH)) ...[more]