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Neural population dynamics in human motor cortex during movements in people with ALS.

ABSTRACT: The prevailing view of motor cortex holds that motor cortical neural activity represents muscle or movement parameters. However, recent studies in non-human primates have shown that neural activity does not simply represent muscle or movement parameters; instead, its temporal structure is well-described by a dynamical system where activity during movement evolves lawfully from an initial pre-movement state. In this study, we analyze neuronal ensemble activity in motor cortex in two clinical trial participants diagnosed with Amyotrophic Lateral Sclerosis (ALS). We find that activity in human motor cortex has similar dynamical structure to that of non-human primates, indicating that human motor cortex contains a similar underlying dynamical system for movement generation.

SUBMITTER: Pandarinath C

PROVIDER: S-EPMC4475900 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Neural population dynamics in human motor cortex during movements in people with ALS.

Pandarinath Chethan C Gilja Vikash V Blabe Christine H CH Nuyujukian Paul P Sarma Anish A AA Sorice Brittany L BL Eskandar Emad N EN Hochberg Leigh R LR Henderson Jaimie M JM Shenoy Krishna V KV

eLife 20150623

The prevailing view of motor cortex holds that motor cortical neural activity represents muscle or movement parameters. However, recent studies in non-human primates have shown that neural activity does not simply represent muscle or movement parameters; instead, its temporal structure is well-described by a dynamical system where activity during movement evolves lawfully from an initial pre-movement state. In this study, we analyze neuronal ensemble activity in motor cortex in two clinical tria ...[more]

PMID: 26099302

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