Ontology highlight
ABSTRACT:
SUBMITTER: Weigelin B
PROVIDER: S-EPMC4475992 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Weigelin Bettina B Bolaños Elixabet E Teijeira Alvaro A Martinez-Forero Ivan I Labiano Sara S Labiano Sara S Azpilikueta Arantza A Morales-Kastresana Aizea A Quetglas José I JI Wagena Esther E Sánchez-Paulete Alfonso Rodríguez AR Chen Lieping L Friedl Peter P Melero Ignacio I
Proceedings of the National Academy of Sciences of the United States of America 20150601 24
Cancer immunotherapy is undergoing significant progress due to recent clinical successes by refined adoptive T-cell transfer and immunostimulatory monoclonal Ab (mAbs). B16F10-derived OVA-expressing mouse melanomas resist curative immunotherapy with either adoptive transfer of activated anti-OVA OT1 CTLs or agonist anti-CD137 (4-1BB) mAb. However, when acting in synergistic combination, these treatments consistently achieve tumor eradication. Tumor-infiltrating lymphocytes that accomplish tumor ...[more]