MiR-146a and miR-155 delineate a MicroRNA fingerprint associated with Toxoplasma persistence in the host brain.
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ABSTRACT:
SUBMITTER: Cannella D
PROVIDER: S-EPMC4476055 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Publications
miR-146a and miR-155 delineate a MicroRNA fingerprint associated with Toxoplasma persistence in the host brain.
Cannella Dominique D Brenier-Pinchart Marie-Pierre MP Braun Laurence L van Rooyen Jason M JM Bougdour Alexandre A Bastien Olivier O Behnke Michael S MS Curt Rose-Laurence RL Curt Aurélie A Saeij Jeroen P J JP Sibley L David LD Pelloux Hervé H Hakimi Mohamed-Ali MA
Cell reports 20140227 5
microRNAs were recently found to be regulators of the host response to infection by apicomplexan parasites. In this study, we identified two immunomodulatory microRNAs, miR-146a and miR-155, that were coinduced in the brains of mice challenged with Toxoplasma in a strain-specific manner. These microRNAs define a characteristic fingerprint for infection by type II strains, which are the most prevalent cause of human toxoplasmosis in Europe and North America. Using forward genetics, we showed that ...[more]
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