Ontology highlight
ABSTRACT:
SUBMITTER: Kraus WL
PROVIDER: S-EPMC4477203 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Molecular cell 20150601 6
Over 50 years ago, the discovery of poly(ADP-ribose) (PAR) set a new field of science in motion-the field of poly(ADP-ribosyl) transferases (PARPs) and ADP-ribosylation. The field is still flourishing today. The diversity of biological processes now known to require PARPs and ADP-ribosylation was practically unimaginable even two decades ago. From an initial focus on DNA damage detection and repair in response to genotoxic stresses, the field has expanded to include the regulation of chromatin s ...[more]