Improvement of antioxidant status after Brazil nut intake in hypertensive and dyslipidemic subjects.

ABSTRACT: To investigate the effect of partially defatted Granulated Brazil nut (GBN) on biomarkers of oxidative stress and antioxidant status of hypertensive and dyslipidemic patients on nutrition and drug approaches.Ninety one hypertensive and dyslipidemic subjects of both genders (51.6 % men), mean age 62.1?±?9.3 years, performed a randomized crossover trial, double-blind, placebo controlled. Subjects received a diet and partially defatted GBN 13 g per day (?227.5 ?g/day of selenium) or placebo for twelve weeks with four-week washout interval. Anthropometric, laboratory and clinic characteristics were investigated at baseline. Plasma selenium (Se), plasma glutathione peroxidase (GPx3) activity, total antioxidant capacity (TAC), 8-epi PGF2? and oxidized LDL were evaluated at the beginning and in the end of each intervention.GBN intake significantly increased plasma Se from 87.0?±?16.8 to 180.6?±?67.1 ?g/L, increased GPx3 activity in 24,8% (from 112.66?±?40.09 to 128.32?±?38.31 nmol/min/mL, p?

SUBMITTER: Huguenin GV 

PROVIDER: S-EPMC4477321 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature