Prenatal maternal immune disruption and sex-dependent risk for psychoses.
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ABSTRACT:
SUBMITTER: Goldstein JM
PROVIDER: S-EPMC4477534 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Publications
Prenatal maternal immune disruption and sex-dependent risk for psychoses.
Goldstein J M JM Cherkerzian S S Seidman L J LJ Donatelli J-A L JA Remington A G AG Tsuang M T MT Hornig M M Buka S L SL
Psychological medicine 20140326 15
<h4>Background</h4>Previous studies suggest that abnormalities in maternal immune activity during pregnancy alter the offspring's brain development and are associated with increased risk for schizophrenia (SCZ) dependent on sex.<h4>Method</h4>Using a nested case-control design and prospectively collected prenatal maternal sera from which interleukin (IL)-1β, IL-8, IL-6, tumor necrosis factor (TNF)-α and IL-10 were assayed, we investigated sex-dependent associations between these cytokines and 88 ...[more]
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