Ontology highlight
ABSTRACT:
SUBMITTER: Yu K
PROVIDER: S-EPMC4477620 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Yu Kuai K Whitlock Jarred M JM Lee Kyleen K Ortlund Eric A EA Cui Yuan Yuan YY Hartzell H Criss HC
eLife 20150609
Phospholipid scrambling (PLS) is a ubiquitous cellular mechanism involving the regulated bidirectional transport of phospholipids down their concentration gradient between membrane leaflets. ANO6/TMEM16F has been shown to be essential for Ca(2+)-dependent PLS, but controversy surrounds whether ANO6 is a phospholipid scramblase or an ion channel like other ANO/TMEM16 family members. Combining patch clamp recording with measurement of PLS, we show that ANO6 elicits robust Ca(2+)-dependent PLS coin ...[more]