Optimal Cutoff Age for Predicting Mortality Associated with Differentiated Thyroid Cancer.

ABSTRACT: Patient's age at the time of diagnosis is an important prognostic factor for differentiated thyroid cancer (DTC) as reflected in various staging and risk stratification systems. However, discrepancies exist among the different staging systems on an optimal cut-off age for predicting the clinical outcome of patients with DTC. To determine the age at diagnosis most predictive of clinical outcomes of DTC, a population-based cohort study was performed composed of 35,323 patients with DTC between 1988 and 2010 using the Surveillance, Epidemiology, and End Results (SEER) database. The Youden index J was used to determine the most predictive age-at-diagnosis for thyroid-cancer-specific death. The multivariate Cox proportional hazards model was used to determine the hazard ratios (HRs) for each ag

SUBMITTER: Kim SJ 

PROVIDER: S-EPMC4477980 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature