Ontology highlight
ABSTRACT:
SUBMITTER: Starks RD
PROVIDER: S-EPMC4478011 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Starks Rachel D RD Beyer Andreas M AM Guo Deng Fu DF Boland Lauren L Zhang Qihong Q Sheffield Val C VC Rahmouni Kamal K
PLoS genetics 20150623 6
Insulin and its receptor are critical for the regulation of metabolic functions, but the mechanisms underlying insulin receptor (IR) trafficking to the plasma membrane are not well understood. Here, we show that Bardet Biedl Syndrome (BBS) proteins are necessary for IR localization to the cell surface. We demonstrate that the IR interacts physically with BBS proteins, and reducing the expression of BBS proteins perturbs IR expression in the cell surface. We show the consequence of disrupting BBS ...[more]