Inference of Network Dynamics and Metabolic Interactions in the Gut Microbiome.
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ABSTRACT:
SUBMITTER: Steinway SN
PROVIDER: S-EPMC4478025 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Publications
Inference of Network Dynamics and Metabolic Interactions in the Gut Microbiome.
Steinway Steven N SN Biggs Matthew B MB Loughran Thomas P TP Papin Jason A JA Albert Reka R
PLoS computational biology 20150501 5
We present a novel methodology to construct a Boolean dynamic model from time series metagenomic information and integrate this modeling with genome-scale metabolic network reconstructions to identify metabolic underpinnings for microbial interactions. We apply this in the context of a critical health issue: clindamycin antibiotic treatment and opportunistic Clostridium difficile infection. Our model recapitulates known dynamics of clindamycin antibiotic treatment and C. difficile infection and ...[more]
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