Ontology highlight
ABSTRACT:
SUBMITTER: Van Landeghem L
PROVIDER: S-EPMC4478798 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Van Landeghem Laurianne L Santoro M Agostina MA Mah Amanda T AT Krebs Adrienne E AE Dehmer Jeffrey J JJ McNaughton Kirk K KK Helmrath Michael A MA Magness Scott T ST Lund P Kay PK
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20150402 7
Insulin-like growth factor 1 (IGF1) has potent trophic effects on normal or injured intestinal epithelium, but specific effects on intestinal stem cells (ISCs) are undefined. We used Sox9-enhanced green fluorescent protein (EGFP) reporter mice that permit analyses of both actively cycling ISCs (Sox9-EGFP(Low)) and reserve/facultative ISCs (Sox9-EGFP(High)) to study IGF1 action on ISCs in normal intestine or during crypt regeneration after high-dose radiation-induced injury. We hypothesized that ...[more]