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Getting our priorities straight: a novel framework for stakeholder-informed prioritization of cancer genomics research.


ABSTRACT: Prioritization of translational research on genomic tests is critically important given the rapid pace of innovation in genomics. The goal of this study was to evaluate a stakeholder-informed priority-setting framework in cancer genomics.An external stakeholder advisory group including patients/consumers, payers, clinicians, and test developers used a modified Delphi approach to prioritize six candidate cancer genomic technologies during a 1-day meeting. Nine qualitative priority-setting criteria were considered. We used a directed, qualitative content-analysis approach to investigate the themes of the meeting discussion.Stakeholders primarily discussed six of the original nine criteria: clinical benefits, population health impacts, economic impacts, analytical and clinical validity, clinical trial implementation and feasibility, and market factors. Several new priority-setting criteria were identified from the workshop transcript, including "patient-reported outcomes," "clinical trial ethics," and "trial recruitment." The new criteria were incorporated with prespecified criteria to develop a novel priority-setting framework.This study highlights key criteria that stakeholders can consider when prioritizing comparative effectiveness research for cancer genomic applications. Applying an explicit priority-setting framework to inform investment in comparative effectiveness research can help to ensure that critical factors are weighed when deciding between many potential research questions and trial designs.

SUBMITTER: Esmail LC 

PROVIDER: S-EPMC4479129 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature

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Getting our priorities straight: a novel framework for stakeholder-informed prioritization of cancer genomics research.

Esmail Laura C LC   Roth Josh J   Rangarao Sneha S   Carlson Josh J JJ   Thariani Rahber R   Ramsey Scott D SD   Veenstra David L DL   Deverka Patricia P  

Genetics in medicine : official journal of the American College of Medical Genetics 20121004 2


<h4>Purpose</h4>Prioritization of translational research on genomic tests is critically important given the rapid pace of innovation in genomics. The goal of this study was to evaluate a stakeholder-informed priority-setting framework in cancer genomics.<h4>Methods</h4>An external stakeholder advisory group including patients/consumers, payers, clinicians, and test developers used a modified Delphi approach to prioritize six candidate cancer genomic technologies during a 1-day meeting. Nine qual  ...[more]

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