Ontology highlight
ABSTRACT:
SUBMITTER: Russ BE
PROVIDER: S-EPMC4479393 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Russ Brendan E BE Olshanksy Moshe M Smallwood Heather S HS Li Jasmine J Denton Alice E AE Prier Julia E JE Stock Angus T AT Croom Hayley A HA Cullen Jolie G JG Nguyen Michelle L T ML Rowe Stephanie S Olson Matthew R MR Finkelstein David B DB Kelso Anne A Thomas Paul G PG Speed Terry P TP Rao Sudha S Turner Stephen J SJ
Immunity 20141106 5
The molecular mechanisms that regulate the rapid transcriptional changes that occur during cytotoxic T lymphocyte (CTL) proliferation and differentiation in response to infection are poorly understood. We have utilized ChIP-seq to assess histone H3 methylation dynamics within naive, effector, and memory virus-specific T cells isolated directly ex vivo after influenza A virus infection. Our results show that within naive T cells, codeposition of the permissive H3K4me3 and repressive H3K27me3 modi ...[more]