Ontology highlight
ABSTRACT:
SUBMITTER: Hanley PJ
PROVIDER: S-EPMC4479400 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Hanley Patrick J PJ Melenhorst Jan J JJ Nikiforow Sarah S Scheinberg Phillip P Blaney James W JW Demmler-Harrison Gail G Cruz C Russell CR Lam Sharon S Krance Robert A RA Leung Kathryn S KS Martinez Caridad A CA Liu Hao H Douek Daniel C DC Heslop Helen E HE Rooney Cliona M CM Shpall Elizabeth J EJ Barrett A John AJ Rodgers John R JR Bollard Catherine M CM
Science translational medicine 20150401 285
Adoptive transfer of cytomegalovirus (CMV)-specific T cells derived from adult seropositive donors can effectively restore antiviral immunity after transplantation. However, CMV-seronegative donors lack CMV-specific memory T cells, which restricts the availability of virus-specific T cells for immunoprophylaxis. We demonstrate the feasibility of deriving CMV-specific T cells from naïve cells for T cell therapy. Naïve T cells primed to recognize CMV were restricted to different, atypical epitopes ...[more]