Ontology highlight
ABSTRACT:
SUBMITTER: Walker CS
PROVIDER: S-EPMC4479521 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Walker Christopher S CS Eftekhari Sajedeh S Bower Rebekah L RL Wilderman Andrea A Insel Paul A PA Edvinsson Lars L Waldvogel Henry J HJ Jamaluddin Muhammad A MA Russo Andrew F AF Hay Debbie L DL
Annals of clinical and translational neurology 20150401 6
<h4>Objective</h4>The trigeminovascular system plays a central role in migraine, a condition in need of new treatments. The neuropeptide, calcitonin gene-related peptide (CGRP), is proposed as causative in migraine and is the subject of intensive drug discovery efforts. This study explores the expression and functionality of two CGRP receptor candidates in the sensory trigeminal system.<h4>Methods</h4>Receptor expression was determined using Taqman G protein-coupled receptor arrays and immunohis ...[more]