Ontology highlight
ABSTRACT:
SUBMITTER: Baffet AD
PROVIDER: S-EPMC4480218 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Baffet Alexandre D AD Hu Daniel J DJ Vallee Richard B RB
Developmental cell 20150604 6
Dynein recruitment to the nuclear envelope is required for pre-mitotic nucleus-centrosome interactions in nonneuronal cells and for apical nuclear migration in neural stem cells. In each case, dynein is recruited to the nuclear envelope (NE) specifically during G2 via two nuclear pore-mediated mechanisms involving RanBP2-BicD2 and Nup133-CENP-F. The mechanisms responsible for cell-cycle control of this behavior are unknown. We now find that Cdk1 serves as a direct master controller for NE dynein ...[more]