Ontology highlight
ABSTRACT:
SUBMITTER: Marroqui L
PROVIDER: S-EPMC4480275 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Marroqui Laura L Lopes Miguel M dos Santos Reinaldo S RS Grieco Fabio A FA Roivainen Merja M Richardson Sarah J SJ Morgan Noel G NG Op de Beeck Anne A Eizirik Decio L DL
eLife 20150610
Type 1 diabetes (T1D) is an autoimmune disease caused by loss of pancreatic β cells via apoptosis while neighboring α cells are preserved. Viral infections by coxsackieviruses (CVB) may contribute to trigger autoimmunity in T1D. Cellular permissiveness to viral infection is modulated by innate antiviral responses, which vary among different cell types. We presently describe that global gene expression is similar in cytokine-treated and virus-infected human islet cells, with up-regulation of gene ...[more]