Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011-2013.
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ABSTRACT:
SUBMITTER: Hawkes M
PROVIDER: S-EPMC4480400 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Publications
Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011-2013.
Hawkes Michael M Conroy Andrea L AL Opoka Robert O RO Namasopo Sophie S Zhong Kathleen K Liles W Conrad WC John Chandy C CC Kain Kevin C KC
Emerging infectious diseases 20150701 7
Plasmodium falciparum resistance to artemisinin derivatives is emerging in Asia. We examined molecular markers of resistance in 78 children in Uganda who had severe malaria and were treated with intravenous artesunate. We observed in the K13-propeller domain, A578S, a low-frequency (3/78), nonsynonymous, single-nucleotide polymorphism associated with prolonged parasite clearance. ...[more]
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