Ontology highlight
ABSTRACT:
SUBMITTER: Asghar U
PROVIDER: S-EPMC4480421 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Asghar Uzma U Witkiewicz Agnieszka K AK Turner Nicholas C NC Knudsen Erik S ES
Nature reviews. Drug discovery 20150201 2
Cancer represents a pathological manifestation of uncontrolled cell division; therefore, it has long been anticipated that our understanding of the basic principles of cell cycle control would result in effective cancer therapies. In particular, cyclin-dependent kinases (CDKs) that promote transition through the cell cycle were expected to be key therapeutic targets because many tumorigenic events ultimately drive proliferation by impinging on CDK4 or CDK6 complexes in the G1 phase of the cell c ...[more]