Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock.
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ABSTRACT:
SUBMITTER: Mantel CR
PROVIDER: S-EPMC4480616 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Publications
Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock.
Mantel Charlie R CR O'Leary Heather A HA Chitteti Brahmananda R BR Huang XinXin X Cooper Scott S Hangoc Giao G Brustovetsky Nickolay N Srour Edward F EF Lee Man Ryul MR Messina-Graham Steven S Haas David M DM Falah Nadia N Kapur Reuben R Pelus Louis M LM Bardeesy Nabeel N Fitamant Julien J Ivan Mircea M Kim Kye-Seong KS Broxmeyer Hal E HE
Cell 20150611 7
Hematopoietic stem cells (HSCs) reside in hypoxic niches within bone marrow and cord blood. Yet, essentially all HSC studies have been performed with cells isolated and processed in non-physiologic ambient air. By collecting and manipulating bone marrow and cord blood in native conditions of hypoxia, we demonstrate that brief exposure to ambient oxygen decreases recovery of long-term repopulating HSCs and increases progenitor cells, a phenomenon we term extraphysiologic oxygen shock/stress (EPHO ...[more]
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