Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production.
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ABSTRACT:
SUBMITTER: Wei HJ
PROVIDER: S-EPMC4480711 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Publications
Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production.
Wei Hong-Jian HJ Zeng Rong R Lu Jui-Hua JH Lai Wen-Fu T WF Chen Wei-Hong WH Liu Hen-Yu HY Chang Ya-Ting YT Deng Win-Ping WP
Oncotarget 20150401 10
Adipose-derived stem cells (ADSCs) are multipotent cells that have attracted much recent attention. Here, we show that ADSCs enhance sphere formation and in vivo tumor initiation of breast and colon cancer cells. In co-culture, ADSCs induced several stem cell markers in cancer cells. ADSCs also accelerated tumor growth. Interaction of ADSCs and cancer cells stimulated secretion of interlukin-6 in ADSCs, which in turn acted in a paracrine manner on cancer cells to enhance their malignant properti ...[more]
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