Ontology highlight
ABSTRACT:
SUBMITTER: Steiner N
PROVIDER: S-EPMC4480745 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Steiner Normann N Ribatti Domenico D Willenbacher Wolfgang W Jöhrer Karin K Kern Johann J Marinaccio Christian C Aracil Miguel M García-Fernández Luis F LF Gastl Guenther G Untergasser Gerold G Gunsilius Eberhard E
Oncotarget 20150401 10
<h4>Purpose</h4>The prognosis of patients with multiple myeloma (MM) is still dismal despite recent improvements achieved by introducing new therapeutic agents. However, there remains an urgent need for progress in myeloma drug development. We here show that novel marine-derived compounds can exert potent anti-myeloma activity.<h4>Experimental design</h4>Nine marine-derived compounds were applied at low nM concentrations (0.1-100 nM) to MM cell lines (OPM-2, NCI-H929, U266, RPMI-8226), to primar ...[more]