Ndrg2 promoter hypermethylation triggered by helicobacter pylori infection correlates with poor patients survival in human gastric carcinoma.
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ABSTRACT:
SUBMITTER: Ling ZQ
PROVIDER: S-EPMC4480746 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Publications
Ndrg2 promoter hypermethylation triggered by helicobacter pylori infection correlates with poor patients survival in human gastric carcinoma.
Ling Zhi-Qiang ZQ Ge Ming-Hua MH Lu Xiao-Xiao XX Han Jin J Wu Yi-Chen YC Liu Xiang X Zhu Xin X Hong Lian-Lian LL
Oncotarget 20150401 10
N-myc downstream regulated gene 2 (Ndrg2) is a candidate suppressor of cancer metastasis. We found that Ndrg2 promoter was frequently hypermethylated in gastric cancer cell lines and in 292 gastric tumor tissues. This resulted in down-regulation of Ndrg2 mRNA and protein. Ndrg2 promoter methylation was associated with H. pylori infection and worse prognosis of gastric cancer patients, which is an independent prognostic factor for the disease-free survival (DFS). We found that H. pylori silenced ...[more]
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