Ontology highlight
ABSTRACT:
SUBMITTER: Meng L
PROVIDER: S-EPMC4481169 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Meng Lingfeng L Mulcahy Ben B Cook Steven J SJ Neubauer Marianna M Wan Airong A Jin Yishi Y Yan Dong D
Cell reports 20150611 11
Synapse elimination occurs in development, plasticity, and disease. Although the importance of synapse elimination has been documented in many studies, the molecular mechanisms underlying this process are unclear. Here, using the development of C. elegans RME neurons as a model, we have uncovered a function for the apoptosis pathway in synapse elimination. We find that the conserved apoptotic cell death (CED) pathway and axonal mitochondria are required for the elimination of transiently formed ...[more]