Ontology highlight
ABSTRACT:
SUBMITTER: Yuan R
PROVIDER: S-EPMC4481683 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Yuan Rong R Gatti Daniel M DM Krier Rebecca R Malay Ethan E Schultz David D Peters Luanne L LL Churchill Gary A GA Harrison David E DE Paigen Beverly B
The journals of gerontology. Series A, Biological sciences and medical sciences 20140728 7
We previously reported that insulin-like growth factor 1 (IGF1) was involved in coregulating female sexual maturation and longevity. To understand the underlying genetic mechanisms, based on the strain survey assays of development and aging traits, we crossed two mouse strains, KK/HIJ and PL/J, and produced 307 female F2 mice. We observed the age of vaginal patency (AVP) and the life span of these females. We also measured circulating IGF1 level at 7, 16, 24, 52, and 76 weeks. IGF1 level at 7 we ...[more]