Ontology highlight
ABSTRACT:
SUBMITTER: Skolakova P
PROVIDER: S-EPMC4482068 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Školáková Petra P Foldynová-Trantírková Silvie S Bednářová Klára K Fiala Radovan R Vorlíčková Michaela M Trantírek Lukáš L
Nucleic acids research 20150408 9
There are two basic mechanisms that are associated with the maintenance of the telomere length, which endows cancer cells with unlimited proliferative potential. One mechanism, referred to as alternative lengthening of telomeres (ALT), accounts for approximately 10-15% of all human cancers. Tumours engaged in the ALT pathway are characterised by the presence of the single stranded 5'-C-rich telomeric overhang (C-overhang). This recently identified hallmark of ALT cancers distinguishes them from ...[more]