Ontology highlight
ABSTRACT:
SUBMITTER: Sherpa C
PROVIDER: S-EPMC4482075 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Sherpa Chringma C Rausch Jason W JW Le Grice Stuart F J SF Hammarskjold Marie-Louise ML Rekosh David D
Nucleic acids research 20150408 9
The HIV Rev protein forms a complex with a 351 nucleotide sequence present in unspliced and incompletely spliced human immunodeficiency virus (HIV) mRNAs, the Rev response element (RRE), to recruit the cellular nuclear export receptor Crm1 and Ran-GTP. This complex facilitates nucleo-cytoplasmic export of these mRNAs. The precise secondary structure of the HIV-1 RRE has been controversial, since studies have reported alternative structures comprising either four or five stem-loops. The published ...[more]