Ontology highlight
ABSTRACT:
SUBMITTER: Wu WQ
PROVIDER: S-EPMC4482088 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Wu Wen-Qiang WQ Hou Xi-Miao XM Li Ming M Dou Shuo-Xing SX Xi Xu-Guang XG
Nucleic acids research 20150420 9
Mutations in the RecQ DNA helicase gene BLM give rise to Bloom's syndrome, which is a rare autosomal recessive disorder characterized by genetic instability and cancer predisposition. BLM helicase is highly active in binding and unwinding G-quadruplexes (G4s), which are physiological targets for BLM, as revealed by genome-wide characterizations of gene expression of cells from BS patients. With smFRET assays, we studied the molecular mechanism of BLM-catalyzed G4 unfolding and showed that ATP is ...[more]