Ontology highlight
ABSTRACT:
SUBMITTER: Ziraldo C
PROVIDER: S-EPMC4482429 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Ziraldo Cordelia C Solovyev Alexey A Allegretti Ana A Krishnan Shilpa S Henzel M Kristi MK Sowa Gwendolyn A GA Brienza David D An Gary G Mi Qi Q Vodovotz Yoram Y
PLoS computational biology 20150625 6
People with spinal cord injury (SCI) are predisposed to pressure ulcers (PU). PU remain a significant burden in cost of care and quality of life despite improved mechanistic understanding and advanced interventions. An agent-based model (ABM) of ischemia/reperfusion-induced inflammation and PU (the PUABM) was created, calibrated to serial images of post-SCI PU, and used to investigate potential treatments in silico. Tissue-level features of the PUABM recapitulated visual patterns of ulcer format ...[more]