Ontology highlight
ABSTRACT:
SUBMITTER: Wang K
PROVIDER: S-EPMC4482727 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Wang Kai K Redeker Virginie V Madiona Karine K Melki Ronald R Kabani Mehdi M
PloS one 20150626 6
Yeast prions are self-perpetuating protein aggregates that cause heritable and transmissible phenotypic traits. Among these, [PSI+] and [URE3] stand out as the most studied yeast prions, and result from the self-assembly of the translation terminator Sup35p and the nitrogen catabolism regulator Ure2p, respectively, into insoluble fibrillar aggregates. Protein quality control systems are well known to govern the formation, propagation and transmission of these prions. However, little is known abo ...[more]