Ontology highlight
ABSTRACT:
SUBMITTER: Puhalla S
PROVIDER: S-EPMC4482864 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Puhalla Shannon S Elmquist William W Freyer David D Kleinberg Lawrence L Adkins Chris C Lockman Paul P McGregor John J Muldoon Leslie L Nesbit Gary G Peereboom David D Smith Quentin Q Walker Sara S Neuwelt Edward E
Neuro-oncology 20150501 5
While the use of targeted therapies, particularly radiosurgery, has broadened therapeutic options for CNS metastases, patients respond minimally and prognosis remains poor. The inability of many systemic chemotherapeutic agents to penetrate the blood-brain barrier (BBB) has limited their use and allowed brain metastases to become a burgeoning clinical challenge. Adequate preclinical models that appropriately mimic the metastatic process, the BBB, and blood-tumor barriers (BTB) are needed to bett ...[more]