Connexin 30 expression inhibits growth of human malignant gliomas but protects them against radiation therapy.

ABSTRACT:

Background

Glioblastomas remain ominous tumors that almost invariably escape treatment. Connexins are a family of transmembrane, gap junction-forming proteins, some members of which were reported to act as tumor suppressors and to modulate cellular metabolism in response to cytotoxic stress.

Methods

We analyzed the copy number and expression of the connexin (Cx)30 gene gap junction beta-6 (GJB6), as well as of its protein immunoreactivity in several public and proprietary repositories of glioblastomas, and their influence on patient survival. We evaluated the effect of the expression of this gap junction protein on the growth, DNA repair and energy metabolism, and treatment resistance of these tumors.

Results

The GJB6 gene was deleted in 25.8% of 751 analyzed tumors a

SUBMITTER: Artesi M 

PROVIDER: S-EPMC4483098 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature