Suppression of miR-184 in malignant gliomas upregulates SND1 and promotes tumor aggressiveness.

ABSTRACT:

Background

Malignant glioma is an aggressive cancer requiring new therapeutic targets. MicroRNAs (miRNAs) regulate gene expression post transcriptionally and are implicated in cancer development and progression. Deregulated expressions of several miRNAs, specifically hsa-miR-184, correlate with glioma development.

Methods

Bioinformatic approaches were used to identify potential miR-184-regulated target genes involved in malignant glioma progression. This strategy identified a multifunctional nuclease, SND1, known to be overexpressed in multiple cancers, including breast, colon, and hepatocellular carcinoma, as a putative direct miR-184 target gene. SND1 levels were evaluated in patient tumor samples and human-derived cell lines. We analyzed invasion and signaling in vitro th

SUBMITTER: Emdad L 

PROVIDER: S-EPMC4483100 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature