Dataset Information

Value of an Additional Review for Eosinophil Quantification in Esophageal Biopsies.

ABSTRACT: Eosinophilic esophagitis (EoE) requires a peak count of 15 eosinophils per high-power field (hpf). Herein, the peak eosinophil count specified by a pathologist was compared with the second review of a research assistant. Of 477 biopsies, 106 had a peak count between 1 and 14 eosinophils/hpf cited in the pathology report, and 23/106 (22%) had ?15 eosinophils/hpf on second review. The pathology report detected potential EoE with 99% specificity, but 80% sensitivity. As such, an additional review of esophageal biopsies yields higher eosinophil counts in ?5% of cases. We propose that biopsies with a count between 1 and 14 eosinophils/hpf require further investigation because ?22% may yield a potential EoE diagnosis.

SUBMITTER: Stucke EM

PROVIDER: S-EPMC4483145 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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Value of an Additional Review for Eosinophil Quantification in Esophageal Biopsies.

Stucke Emily M EM Clarridge Katherine E KE Collins Margaret H MH Henderson Carol J CJ Martin Lisa J LJ Rothenberg Marc E ME

Journal of pediatric gastroenterology and nutrition 20150701 1

Eosinophilic esophagitis (EoE) requires a peak count of 15 eosinophils per high-power field (hpf). Herein, the peak eosinophil count specified by a pathologist was compared with the second review of a research assistant. Of 477 biopsies, 106 had a peak count between 1 and 14 eosinophils/hpf cited in the pathology report, and 23/106 (22%) had ≥15 eosinophils/hpf on second review. The pathology report detected potential EoE with 99% specificity, but 80% sensitivity. As such, an additional review o ...[more]

PMID: 25633495

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Dataset Information

Value of an Additional Review for Eosinophil Quantification in Esophageal Biopsies.

Publications

Value of an Additional Review for Eosinophil Quantification in Esophageal Biopsies.

Similar Datasets

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