Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC4483218 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Liu Xiaoke X Xu Yong Y Pang Zongguo Z Guo Fuchun F Qin Qing Q Yin Tao T Sang Yaxiong Y Feng Chengjun C Li Xiaoyu X Jiang Li L Shu Pei P Wang Yongsheng Y
Journal of hematology & oncology 20150611
<h4>Background</h4>SUMO-activating enzyme subunit 2 (SAE2) is the sole E1-activating enzyme required for numerous important protein SUMOylation, abnormal of which is associated with carcinogenesis. SAE2 inactivation was recently reported to be a therapeutic strategy in cancers with Myc overexpression. However, the roles of SAE2 in small cell lung cancer (SCLC) are largely unknown.<h4>Methods</h4>Stably SAE2 knockdown in H446 cells were established with a lentiviral system. Cell viability, cell c ...[more]