Nephron Deficiency and Predisposition to Renal Injury in a Novel One-Kidney Genetic Model.

ABSTRACT: Some studies have reported up to 40% of patients born with a single kidney develop hypertension, proteinuria, and in some cases renal failure. The increased susceptibility to renal injury may be due, in part, to reduced nephron numbers. Notably, children who undergo nephrectomy or adults who serve as kidney donors exhibit little difference in renal function compared with persons who have two kidneys. However, the difference in risk between being born with a single kidney versus being born with two kidneys and then undergoing nephrectomy are unclear. Animal models used previously to investigate this question are not ideal because they require invasive methods to model congenital solitary kidney. In this study, we describe a new genetic animal model, the heterogeneous stock-derived model of

SUBMITTER: Wang X 

PROVIDER: S-EPMC4483580 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature