Ontology highlight
ABSTRACT:
SUBMITTER: Cao W
PROVIDER: S-EPMC4483588 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Cao Wei W Li Aiqing A Wang Liangliang L Zhou Zhanmei Z Su Zhengxiu Z Bin Wei W Wilcox Christopher S CS Hou Fan Fan FF
Journal of the American Society of Nephrology : JASN 20150129 7
Salt intake promotes progression of CKD by uncertain mechanisms. We hypothesized that a salt-induced reno-cerebral reflex activates a renin-angiotensin axis to promote CKD. Sham-operated and 5/6-nephrectomized rats received a normal-salt (0.4%), low-salt (0.02%), or high-salt (4%) diet for 2 weeks. High salt in 5/6-nephrectomized rats increased renal NADPH oxidase, inflammation, BP, and albuminuria. Furthermore, high salt activated the intrarenal and cerebral, but not the systemic, renin-angiote ...[more]