Ontology highlight
ABSTRACT:
SUBMITTER: Kikuchi E
PROVIDER: S-EPMC4483590 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Kikuchi Eriko E Mori Takayasu T Zeniya Moko M Isobe Kiyoshi K Ishigami-Yuasa Mari M Fujii Shinya S Kagechika Hiroyuki H Ishihara Tomoaki T Mizushima Tohru T Sasaki Sei S Sohara Eisei E Rai Tatemitsu T Uchida Shinichi S
Journal of the American Society of Nephrology : JASN 20141105 7
Upon activation by with-no-lysine kinases, STE20/SPS1-related proline-alanine-rich protein kinase (SPAK) phosphorylates and activates SLC12A transporters such as the Na(+)-Cl(-) cotransporter (NCC) and Na(+)-K(+)-2Cl(-) cotransporter type 1 (NKCC1) and type 2 (NKCC2); these transporters have important roles in regulating BP through NaCl reabsorption and vasoconstriction. SPAK knockout mice are viable and display hypotension with decreased activity (phosphorylation) of NCC and NKCC1 in the kidney ...[more]