Ontology highlight
ABSTRACT:
SUBMITTER: Galasiti Kankanamalage AC
PROVIDER: S-EPMC4484267 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Galasiti Kankanamalage Anushka C AC Kim Yunjeong Y Weerawarna Pathum M PM Uy Roxanne Adeline Z RA Damalanka Vishnu C VC Mandadapu Sivakoteswara Rao SR Alliston Kevin R KR Mehzabeen Nurjahan N Battaile Kevin P KP Lovell Scott S Chang Kyeong-Ok KO Groutas William C WC
Journal of medicinal chemistry 20150319 7
Norovirus infection constitutes the primary cause of acute viral gastroenteritis. There are currently no vaccines or norovirus-specific antiviral therapeutics available for the management of norovirus infection. Norovirus 3C-like protease is essential for viral replication, consequently, inhibition of this enzyme is a fruitful avenue of investigation that may lead to the emergence of antinorovirus therapeutics. We describe herein the optimization of dipeptidyl inhibitors of norovirus 3C-like pro ...[more]