Ontology highlight
ABSTRACT:
SUBMITTER: Conti A
PROVIDER: S-EPMC4484434 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Conti Annalisa A Majorini Maria Teresa MT Elliott Richard R Ashworth Alan A Lord Christopher J CJ Cancelliere Carlotta C Bardelli Alberto A Seneci Pierfausto P Walczak Henning H Delia Domenico D Lecis Daniele D
Oncotarget 20150501 13
KRAS is mutated in about 20-25% of all human cancers and especially in pancreatic, lung and colorectal tumors. Oncogenic KRAS stimulates several pro-survival pathways, but it also triggers the trans-activation of pro-apoptotic genes. In our work, we show that G13D mutations of KRAS activate the MAPK pathway, and ERK2, but not ERK1, up-regulates Noxa basal levels. Accordingly, premalignant epithelial cells are sensitized to various cytotoxic compounds in a Noxa-dependent manner. In contrast to th ...[more]