Ontology highlight
ABSTRACT:
SUBMITTER: Ding J
PROVIDER: S-EPMC4484481 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Ding Jin J Wen Wen W Xiang Daimin D Yin Peipei P Liu Yanfang Y Liu Chang C He Guoping G Cheng Zhuo Z Yin Jianpeng J Sheng Chunquan C Zhang Wen W Nan Fajun F Ye Wencai W Zhang Xiuli X Wang Hongyang H
Oncotarget 20150501 13
Resistance of hepatocellular carcinoma (HCC) to existing chemotherapeutic agents largely contributes to the poor prognosis of patients, and discovery of novel anti-HCC drug is in an urgent need. Herein we report ψ-Bufarenogin, a novel active compound that we isolated from the extract of toad skin, exhibited potent therapeutic effect in xenografted human hepatoma without notable side effects. In vitro, ψ-Bufarenogin suppressed HCC cells proliferation through impeding cell cycle progression, and i ...[more]