Ontology highlight
ABSTRACT:
SUBMITTER: Hakimi P
PROVIDER: S-EPMC4484620 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Hakimi Parvin P Yang Jianqi J Casadesus Gemma G Massillon Duna D Tolentino-Silva Fatima F Nye Colleen K CK Cabrera Marco E ME Hagen David R DR Utter Christopher B CB Baghdy Yacoub Y Johnson David H DH Wilson David L DL Kirwan John P JP Kalhan Satish C SC Hanson Richard W RW
The Journal of biological chemistry 20070823 45
Transgenic mice, containing a chimeric gene in which the cDNA for phosphoenolpyruvate carboxykinase (GTP) (PEPCK-C) (EC 4.1.1.32) was linked to the alpha-skeletal actin gene promoter, express PEPCK-C in skeletal muscle (1-3 units/g). Breeding two founder lines together produced mice with an activity of PEPCK-C of 9 units/g of muscle (PEPCK-C(mus) mice). These mice were seven times more active in their cages than controls. On a mouse treadmill, PEPCK-C(mus) mice ran up to 6 km at a speed of 20 m/ ...[more]