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Acylsulfonamide-Functionalized Zwitterionic Gold Nanoparticles for Enhanced Cellular Uptake at Tumor pH.


ABSTRACT: A nanoparticle design featuring pH-responsive alkoxyphenyl acylsulfonamide ligands is reported herein. As a result of ligand structure, this nanoparticle is neutral at pH?7.4, becoming positively charged at tumor?pH (<6.5). The particle uptake and cytotoxicity increase over this pH?range. This pH-controlled uptake and toxicity makes this particle a promising tool for tumor selective therapy.

SUBMITTER: Mizuhara T 

PROVIDER: S-EPMC4484729 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature

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Acylsulfonamide-Functionalized Zwitterionic Gold Nanoparticles for Enhanced Cellular Uptake at Tumor pH.

Mizuhara Tsukasa T   Saha Krishnendu K   Moyano Daniel F DF   Kim Chang Soo CS   Yan Bo B   Kim Young-Kwan YK   Rotello Vincent M VM  

Angewandte Chemie (International ed. in English) 20150414 22


A nanoparticle design featuring pH-responsive alkoxyphenyl acylsulfonamide ligands is reported herein. As a result of ligand structure, this nanoparticle is neutral at pH 7.4, becoming positively charged at tumor pH (<6.5). The particle uptake and cytotoxicity increase over this pH range. This pH-controlled uptake and toxicity makes this particle a promising tool for tumor selective therapy. ...[more]

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