Ontology highlight
ABSTRACT:
SUBMITTER: Miao J
PROVIDER: S-EPMC4484737 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Miao Ji J Manthena Praveen V PV Haas Mary E ME Ling Alisha V AV Shin Dong-Ju DJ Graham Mark J MJ Crooke Rosanne M RM Liu Jingwen J Biddinger Sudha B SB
Arteriosclerosis, thrombosis, and vascular biology 20150528 7
<h4>Objective</h4>Proprotein convertase subtilisin/kexin type 9 (PCSK9), which binds the low-density lipoprotein receptor and targets it for degradation, has emerged as an important regulator of serum cholesterol levels and cardiovascular disease risk. Although much work is currently focused on developing therapies for inhibiting PCSK9, the endogenous regulation of PCSK9, particularly by insulin, remains unclear. The objective of these studies was to determine the effects of insulin on PCSK9 in ...[more]