Ontology highlight
ABSTRACT:
SUBMITTER: Salles FT
PROVIDER: S-EPMC4484851 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Salles Felipe T FT Andrade Leonardo R LR Tanda Soichi S Grati M'hamed M Plona Kathleen L KL Gagnon Leona H LH Johnson Kenneth R KR Kachar Bechara B Berryman Mark A MA
Cytoskeleton (Hoboken, N.J.) 20131210 1
Chloride intracellular channel 5 protein (CLIC5) was originally isolated from microvilli in complex with actin binding proteins including ezrin, a member of the Ezrin-Radixin-Moesin (ERM) family of membrane-cytoskeletal linkers. CLIC5 concentrates at the base of hair cell stereocilia and is required for normal hearing and balance in mice, but its functional significance is poorly understood. This study investigated the role of CLIC5 in postnatal development and maintenance of hair bundles. Confo ...[more]