Genetic Approaches to Facilitate Antibacterial Drug Development.
Ontology highlight
ABSTRACT:
SUBMITTER: Schnappinger D
PROVIDER: S-EPMC4484962 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
Genetic Approaches to Facilitate Antibacterial Drug Development.
Cold Spring Harbor perspectives in medicine 20150213 7
Very few chemically novel agents have been approved for antibacterial chemotherapies during the last 50 yr. Yet new antibacterial drugs are needed to reduce the impact on global health of an increasing number of drug-resistant infections, including highly drug-resistant forms of tuberculosis. This review discusses how genetic approaches can be used to study the mechanism of action of whole-cell screening hits and facilitate target-driven strategies for antimicrobial drug development. ...[more]
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